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The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.

ABSTRACT: The Drosophila neuromuscular junction (NMJ) has recently provided new insights into the roles of various proteins in neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), Multiple Sclerosis (MS) Hereditary Spastic Paraplegia (HSP), and Huntington's Disease (HD). Several developmental signaling pathways including WNT, MAPK and BMP/TGF-? signaling play important roles in the formation and growth of the Drosophila NMJ. Studies of the fly homologues of genes that cause neurodegenerative disease at the NMJ have resulted in a better understanding of the roles of these proteins in vivo. These studies may shed light on the pathological mechanisms of these diseases, with implications for reduced BMP/TGF-? signaling in ALS, SMA and HD and increased signaling in HSP and MS.

SUBMITTER: Bayat V

PROVIDER: S-EPMC3095363 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.

Bayat Vafa V Jaiswal Manish M Bellen Hugo J HJ

Current opinion in neurobiology 20100909 1

The Drosophila neuromuscular junction (NMJ) has recently provided new insights into the roles of various proteins in neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), Multiple Sclerosis (MS) Hereditary Spastic Paraplegia (HSP), and Huntington's Disease (HD). Several developmental signaling pathways including WNT, MAPK and BMP/TGF-β signaling play important roles in the formation and growth of the Drosophila NMJ. Studies of the fly homologues ...[more]

PMID: 20832291

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Correction: A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction.

Project description:[This corrects the article DOI: 10.1371/journal.pgen.1005810.].

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