The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease.

ABSTRACT:

Background

The biological functions of epicardial adipose tissue (EAT) remain largely unknown. However, the proximity of EAT to the coronary arteries suggests a role in the pathogenesis of coronary artery disease (CAD). The objectives of this study were to identify genes differentially regulated among three adipose tissues, namely EAT, mediastinal (MAT) and subcutaneous (SAT) and to study their possible relationships with the development of cardiovascular diseases.

Methods and results

Samples were collected from subjects undergoing coronary artery bypass grafting surgeries. Gene expression was evaluated in the three adipose depots of six men using the Illumina® HumanWG-6 v3.0 expression BeadChips. Twenty-three and 73 genes were differentially up-regulated in EAT compared to

SUBMITTER: Guauque-Olarte S 

PROVIDER: S-EPMC3095619 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature