Ontology highlight
ABSTRACT:
SUBMITTER: Mogila V
PROVIDER: S-EPMC3095892 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Developmental cell 20061001 4
Cell cycle checkpoints are surveillance mechanisms that safeguard genome integrity. While the extrinsic pathways that halt the cell cycle in response to DNA damages have been well documented, the intrinsic pathways that ensure orderly progression of cell cycle events are not well understood. We demonstrate that Drosophila MEK and ERK constitute an essential intrinsic checkpoint pathway that restrains cell cycle progression in the absence of DNA damage and also responds to ionizing radiation to a ...[more]