A novel network model identified a 13-gene lung cancer prognostic signature.
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ABSTRACT:
SUBMITTER: Guo NL
PROVIDER: S-EPMC3095973 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
A novel network model identified a 13-gene lung cancer prognostic signature.
Guo Nancy Lan NL Wan Ying-Wooi YW Bose Swetha S Denvir James J Kashon Michael L ML Andrew Michael E ME
International journal of computational biology and drug design 20110217 1
This study presents a novel network methodology to identify prognostic gene signatures. Implication networks based on prediction logic are used to construct genome-wide coexpression networks for different disease states. From the differential components associated with specific disease states, candidate genes that are co-expressed with major disease signal hallmarks are selected. From these candidate genes, top genes that are the most predictive of clinical outcome are identified using univariat ...[more]
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