Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC3096519 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Fang Xin X Huang Tao T Zhu Ying Y Yan Qiaojing Q Chi Yuan Y Jiang Jean X JX Wang Peiyu P Matsue Hiroyuki H Kitamura Masanori M Yao Jian J
Antioxidants & redox signaling 20110331 12
We investigated the potential involvement of connexin hemichannels in cadmium ions (Cd(2+))-elicited cell injury. Transfection of LLC-PK1 cells with a wild-type connexin43 (Cx43) sensitized them to Cd(2+)-elicited cell injury. The cell susceptibility to Cd(2+) was increased by depletion of glutathione (GSH) with DL-buthionine-[S,R]-sulfoximine, and decreased by N-acetyl-cysteine or glutathione reduced ethyl ester. Fibroblasts derived from Cx43 wild-type (Cx43+/+) and knockout (Cx43-/-) fetal lit ...[more]