Ontology highlight
ABSTRACT:
SUBMITTER: Gabriely G
PROVIDER: S-EPMC3096675 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Gabriely Galina G Yi Ming M Narayan Ravi S RS Niers Johanna M JM Wurdinger Thomas T Imitola Jaime J Ligon Keith L KL Kesari Santosh S Esau Christine C Stephens Robert M RM Tannous Bakhos A BA Krichevsky Anna M AM
Cancer research 20110406 10
MicroRNA (miRNA) expression profiling studies revealed a number of miRNAs dysregulated in the malignant brain tumor glioblastoma. Molecular functions of these miRNAs in gliomagenesis are mainly unknown. We show that inhibition of miR-10b, a miRNA not expressed in human brain and strongly upregulated in both low-grade and high-grade gliomas, reduces glioma cell growth by cell-cycle arrest and apoptosis. These cellular responses are mediated by augmented expression of the direct targets of miR-10b ...[more]