Cohesins coordinate gene transcriptions of related function within Saccharomyces cerevisiae.

ABSTRACT: Cohesion factors pair together sister chromatids from early S-phase until anaphase onset. Numerous findings also establish an additional role in transcription. In humans, mutations in cohesion factors result in developmental abnormalities such as Cornelia de Lange, Roberts Syndrome/SC-Phocomelia, Rothman-Thompson Syndrome and others. While clinically relevant, a detailed study that links experimentally-defined cohesin defects to transcriptional changes remains lacking. Here, we report on the effects of cohesin inactivation during an early and discrete portion of the cell cycle. Even transient cohesin inactivation during the G1 portion of the cell cycle results in significant and reproducible changes in transcription. Surprisingly, over a third of the affected genes exhibit inter-related fu

SUBMITTER: Skibbens RV 

PROVIDER: S-EPMC3096706 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature