Ontology highlight
ABSTRACT:
SUBMITTER: Skibbens RV
PROVIDER: S-EPMC3096706 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20100415 8
Cohesion factors pair together sister chromatids from early S-phase until anaphase onset. Numerous findings also establish an additional role in transcription. In humans, mutations in cohesion factors result in developmental abnormalities such as Cornelia de Lange, Roberts Syndrome/SC-Phocomelia, Rothman-Thompson Syndrome and others. While clinically relevant, a detailed study that links experimentally-defined cohesin defects to transcriptional changes remains lacking. Here, we report on the eff ...[more]