Ontology highlight
ABSTRACT:
SUBMITTER: Mantoni TS
PROVIDER: S-EPMC3097171 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Mantoni Tine S TS Lunardi Serena S Al-Assar Osama O Masamune Atsushi A Brunner Thomas B TB
Cancer research 20110510 10
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and stimulate proliferation in pancreatic cancer cells (PCC) in direct coculture. Our in vivo studies show ...[more]