Ontology highlight
ABSTRACT:
SUBMITTER: Arteaga-Solis E
PROVIDER: S-EPMC3097426 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Matrix biology : journal of the International Society for Matrix Biology 20110329 3
The contribution of non-collagenous components of the extracellular matrix to bone strength is largely undefined. Here we report that deficiency of fibrillin-1 or fibrillin-2 microfibrils causes distinct changes in bone material and mechanical properties. Morphometric examination of mice with hypomorphic or null mutations in fibrillin-1 or fibrillin-2, respectively, revealed appreciable differences in the postnatal shaping and growth of long bones. Fourier transform infrared imaging spectroscopy ...[more]