Ontology highlight
ABSTRACT:
SUBMITTER: Hunt AR
PROVIDER: S-EPMC3097527 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Hunt Ann R AR Bowen Richard A RA Frederickson Shana S Maruyama Toshiaki T Roehrig John T JT Blair Carol D CD
Virology 20110413 2
We recently described a Venezuelan equine encephalitis virus (VEEV)-specific human monoclonal antibody (MAb), F5 nIgG, that recognizes a new neutralization epitope on the VEEV E2 envelope glycoprotein. In this study, we investigated the ability of F5 nIgG given prophylactically or therapeutically to protect mice from subcutaneous or aerosolized VEEV infection. F5 nIgG had potent ability to protect mice from infection by either route when administered 24h before exposure; however, mice treated 24 ...[more]