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Rapid determination of enantiomeric excess of ?-chiral cyclohexanones using circular dichroism spectroscopy.

ABSTRACT: Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [Cu(I)((S)-1)(CH(3)CN)(2)]PF(6) and derivatized ?-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS).

SUBMITTER: Leung D

PROVIDER: S-EPMC3097997 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Rapid determination of enantiomeric excess of α-chiral cyclohexanones using circular dichroism spectroscopy.

Leung Diana D Anslyn Eric V EV

Organic letters 20110412 9

Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [Cu(I)((S)-1)(CH(3)CN)(2)]PF(6) and derivatized α-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS). ...[more]

PMID: 21486023

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