Ontology highlight
ABSTRACT:
SUBMITTER: Megli CJ
PROVIDER: S-EPMC3098003 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Megli Christina J CJ Yuen Alex S W AS Kolappan Subramaniapillai S Richardson Malcolm R MR Dharmasena Madushini N MN Krebs Shelly J SJ Taylor Ronald K RK Craig Lisa L
Journal of molecular biology 20110401 2
Vibrio cholerae relies on two main virulence factors--toxin-coregulated pilus (TCP) and cholera toxin--to cause the gastrointestinal disease cholera. TCP is a type IV pilus that mediates bacterial autoagglutination and colonization of the intestine. TCP is encoded by the tcp operon, which also encodes TcpF, a protein of unknown function that is secreted by V. cholerae in a TCP-dependent manner. Although TcpF is not required for TCP biogenesis, a tcpF mutant has a colonization defect in the infan ...[more]