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Polymorphisms in interferon regulatory factor 7 reduce interferon-? responses of plasmacytoid dendritic cells to HIV-1.

ABSTRACT: Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-? (IFN-?), and the ability of plasmacytoid dendritic cells to produce IFN-? in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of individuals to respond to HIV-1 and modulate HIV-1 disease progression.

SUBMITTER: Chang J

PROVIDER: S-EPMC3098498 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1.

Chang Judy J Lindsay Robert J RJ Kulkarni Smita S Lifson Jeffrey D JD Carrington Mary M Altfeld Marcus M

AIDS (London, England) 20110301 5

Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-α (IFN-α), and the ability of plasmacytoid dendritic cells to produce IFN-α in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of indiv ...[more]

PMID: 21297422

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