Ontology highlight
ABSTRACT:
SUBMITTER: Mekahli D
PROVIDER: S-EPMC3098671 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Mekahli Djalila D Bultynck Geert G Parys Jan B JB De Smedt Humbert H Missiaen Ludwig L
Cold Spring Harbor perspectives in biology 20110601 6
The endoplasmic reticulum (ER) as an intracellular Ca(2+) store not only sets up cytosolic Ca(2+) signals, but, among other functions, also assembles and folds newly synthesized proteins. Alterations in ER homeostasis, including severe Ca(2+) depletion, are an upstream event in the pathophysiology of many diseases. On the one hand, insufficient release of activator Ca(2+) may no longer sustain essential cell functions. On the other hand, loss of luminal Ca(2+) causes ER stress and activates an u ...[more]