Ontology highlight
ABSTRACT:
SUBMITTER: Smith AJ
PROVIDER: S-EPMC3098930 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Smith Anthony J AJ Toledo Chad M CM Wietgrefe Stephen W SW Duan Lijie L Schacker Timothy W TW Reilly Cavan S CS Haase Ashley T AT
Journal of immunology (Baltimore, Md. : 1950) 20110427 11
One pathological hallmark of HIV-1 infection is chronic activation of the immune system, driven, in part, by increased expression of proinflammatory cytokines. The host attempts to counterbalance this prolonged immune activation through compensatory mediators of immune suppression. We recently identified a gene encoding the proinflammatory cytokine IL-32 in microarray studies of HIV-1 infection in lymphatic tissue (LT) and show in this study that increased expression of IL-32 in both gut and LT ...[more]