Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC3099645 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Organic letters 20101101 21
An enantiospecific total synthesis of the pyrrole-imidazole natural product cyclooroidin from histidine is described. The key N1-C9 bond is constructed through an intramolecular SN2-type of reaction of a chloro ester. Subsequent imidazole azidation at the 2-position, pyrrole bromination, azide reduction, and deprotection leads to the completion of the synthesis. ...[more]