DNA methylation and demethylation in mammals.
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ABSTRACT:
SUBMITTER: Chen ZX
PROVIDER: S-EPMC3099650 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
DNA methylation and demethylation in mammals.
Chen Zhao-xia ZX Riggs Arthur D AD
The Journal of biological chemistry 20110324 21
Cell type-specific DNA methylation patterns are established during mammalian development and maintained in adult somatic cells. Understanding how these patterns of 5-methylcytosine are established and maintained requires the elucidation of mechanisms for both DNA methylation and demethylation. The enzymes involved in the de novo methylation of DNA and the maintenance of the resulting methylation patterns have been fairly well characterized. However, important remaining challenges are to understa ...[more]
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