Ontology highlight
ABSTRACT:
SUBMITTER: Hamamura K
PROVIDER: S-EPMC3099669 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Hamamura Kazunori K Tsuji Momoko M Hotta Hiroshi H Ohkawa Yuki Y Takahashi Masataka M Shibuya Hidenobu H Nakashima Hideyuki H Yamauchi Yoshio Y Hashimoto Noboru N Hattori Hisashi H Ueda Minoru M Furukawa Keiko K Furukawa Koichi K
The Journal of biological chemistry 20110331 21
The possible roles of Src family kinases in the enhanced malignant properties of melanomas related to GD3 expression were analyzed. Among Src family kinases only Yes, not Fyn or Src, was functionally involved in the increased cell proliferation and invasion of GD3-expressing transfectant cells (GD3+). Yes was located upstream of p130Cas and paxillin and at an equivalent level to focal adhesion kinase. Yes underwent autophosphorylation even before serum treatment and showed stronger kinase activi ...[more]