Ontology highlight
ABSTRACT:
SUBMITTER: Horsch M
PROVIDER: S-EPMC3099677 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110405 21
ADAR2, an RNA editing enzyme that converts specific adenosines to inosines in certain pre-mRNAs, often leading to amino acid substitutions in the encoded proteins, is mainly expressed in brain. Of all ADAR2-mediated edits, a single one in the pre-mRNA of the AMPA receptor subunit GluA2 is essential for survival. Hence, early postnatal death of mice lacking ADAR2 is averted when the critical edit is engineered into both GluA2 encoding Gria2 alleles. Adar2(-/-)/Gria2(R/R) mice display normal appea ...[more]