Ontology highlight
ABSTRACT:
SUBMITTER: Aertgeerts K
PROVIDER: S-EPMC3099692 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Aertgeerts Kathleen K Skene Robert R Yano Jason J Sang Bi-Ching BC Zou Hua H Snell Gyorgy G Jennings Andy A Iwamoto Keiji K Habuka Noriyuki N Hirokawa Aki A Ishikawa Tomoyasu T Tanaka Toshimasa T Miki Hiroshi H Ohta Yoshikazu Y Sogabe Satoshi S
The Journal of biological chemistry 20110330 21
Aberrant signaling of ErbB family members human epidermal growth factor 2 (HER2) and epidermal growth factor receptor (EGFR) is implicated in many human cancers, and HER2 expression is predictive of human disease recurrence and prognosis. Small molecule kinase inhibitors of EGFR and of both HER2 and EGFR have received approval for the treatment of cancer. We present the first high resolution crystal structure of the kinase domain of HER2 in complex with a selective inhibitor to understand protei ...[more]