Ontology highlight
ABSTRACT:
SUBMITTER: Valkonen M
PROVIDER: S-EPMC309985 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Applied and environmental microbiology 20031201 12
Unfolded-protein response (UPR) denotes the upregulation of endoplasmic reticulum (ER)-resident chaperone and foldase genes and numerous other genes involved in secretory functions during the accumulation of unfolded proteins into the ER. Overexpression of individual foldases and chaperones has been used in attempts to improve protein production in different production systems. We describe here a novel strategy to improve foreign-protein production. We show that the constitutive induction of the ...[more]