Melanocortin signaling in the CNS directly regulates circulating cholesterol.
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ABSTRACT:
SUBMITTER: Perez-Tilve D
PROVIDER: S-EPMC3100172 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Melanocortin signaling in the CNS directly regulates circulating cholesterol.
Perez-Tilve Diego D Hofmann Susanna M SM Basford Joshua J Nogueiras Ruben R Pfluger Paul T PT Patterson James T JT Grant Erin E Wilson-Perez Hilary E HE Granholm Norman A NA Arnold Myrtha M Trevaskis James L JL Butler Andrew A AA Davidson William S WS Woods Stephen C SC Benoit Stephen C SC Sleeman Mark W MW DiMarchi Richard D RD Hui David Y DY Tschöp Matthias H MH
Nature neuroscience 20100606 7
Cholesterol circulates in the blood in association with triglycerides and other lipids, and elevated blood low-density lipoprotein cholesterol carries a risk for metabolic and cardiovascular disorders, whereas high-density lipoprotein (HDL) cholesterol in the blood is thought to be beneficial. Circulating cholesterol is the balance among dietary cholesterol absorption, hepatic synthesis and secretion, and the metabolism of lipoproteins by various tissues. We found that the CNS is also an importa ...[more]
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