Ontology highlight
ABSTRACT:
SUBMITTER: Reikvam H
PROVIDER: S-EPMC3100545 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Reikvam Håkon H Hatfield Kimberley Joanne KJ Kittang Astrid Olsnes AO Hovland Randi R Bruserud Øystein Ø
Journal of biomedicine & biotechnology 20110503
The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effects on the regulation of the proliferation, the differentiation, and the viability of leukemic cells. The translocation can be detected as the only genetic abnormality or as part of more complex abnor ...[more]