Ontology highlight
ABSTRACT:
SUBMITTER: Song R
PROVIDER: S-EPMC3100575 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Song Renfang R El-Dahr Samir S SS Yosypiv Ihor V IV
Journal of signal transduction 20110303
The kidney plays a fundamental role in the regulation of arterial blood pressure and fluid/electrolyte homeostasis. As congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most common human birth defects, improved understanding of the cellular and molecular mechanisms that lead to CAKUT is critical. Accumulating evidence indicates that aberrant signaling via receptor tyrosine kinases (RTKs) is causally linked to CAKUT. Upon activation by their ligands, RTKs dimerize ...[more]