Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse.
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ABSTRACT:
SUBMITTER: Belknap JK
PROVIDER: S-EPMC3100800 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse.
Belknap John K JK Metten Pamela P Beckley Ethan H EH Crabbe John C JC
Trends in pharmacological sciences 20080904 11
Vulnerability to abused drugs is influenced by multiple genes unique to each drug and to risk genes for polydrug abuse. If several inbred mouse strains respond to different drugs similarly, this implies the action of a common group of genes. Simultaneous analysis of multiple responses to multiple drugs has been attempted infrequently. We performed multivariate analyses of published strain responses to four drugs. Genetic similarity in responses did not simply track pharmacological class. Withdra ...[more]
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