Ontology highlight
ABSTRACT:
SUBMITTER: Sael L
PROVIDER: S-EPMC3100846 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20101206 12
Functional elucidation of uncharacterized protein structures is an important task in bioinformatics. We report our new approach for structure-based function prediction which captures local surface features of ligand binding pockets. Function of proteins, specifically, binding ligands of proteins, can be predicted by finding similar local surface regions of known proteins. To enable partial comparison of binding sites in proteins, a weighted bipartite matching algorithm is used to match pairs of ...[more]