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Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.

ABSTRACT: Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.

SUBMITTER: Wen YZ

PROVIDER: S-EPMC3100955 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.

Wen Yan-Zi YZ Zheng Ling-Ling LL Liao Jian-You JY Wang Ming-Hui MH Wei Ying Y Guo Xue-Min XM Qu Liang-Hu LH Ayala Francisco J FJ Lun Zhao-Rong ZR

Proceedings of the National Academy of Sciences of the United States of America 20110429 20

Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes an ...[more]

PMID: 21531904

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