Ontology highlight
ABSTRACT:
SUBMITTER: Wacheck V
PROVIDER: S-EPMC3101112 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Wacheck Volker V Lahn Michael M Dickinson Gemma G Füreder Wolfgang W Meyer Renata R Herndlhofer Susanne S Füreder Thorsten T Dorfner Georg G Pillay Sada S André Valérie V Burkholder Timothy P TP Akunda Jacqueline K JK Flye-Blakemore Leann L Van Bockstaele Dirk D Schlenk Richard F RF Sperr Wolfgang R WR Valent Peter P
Cancer management and research 20110510
<h4>Background</h4>Acute myeloid leukemia (AML) is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2457546, a novel multikinase inhibitor, in patients with relapsed AML.<h4>Methods</h4>In this nonrandomized, open-label, dose escalation Phase I study, LY2457546 was administered orally once a day. Safety, pharmacokinetics, changes in phosphory ...[more]