Ontology highlight
ABSTRACT:
SUBMITTER: Kuettel S
PROVIDER: S-EPMC3101181 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Kuettel Sabine S Greenwald Jason J Kostrewa Dirk D Ahmed Shaheen S Scapozza Leonardo L Perozzo Remo R
PLoS neglected tropical diseases 20110524 5
<h4>Background</h4>The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of the key enzymes is adenosine kinase which catalyzes the phosphorylation of ingested adenosine to form adenosine monophosphate (AMP) utilizing adenosine triphosphate (ATP) as the preferred phospho ...[more]