FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.
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ABSTRACT:
SUBMITTER: Ohyama T
PROVIDER: S-EPMC310202 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
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FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.
Ohyama Takao T Miyakoshi Shunichi S Isono Fujio F
Antimicrobial agents and chemotherapy 20040101 1
Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-beta-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn(470) with Lys or of Leu(642) with Ser confers selective resistance on Fks1p mutants. ...[more]
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