Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.
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SUBMITTER: Perneczky R
PROVIDER: S-EPMC3102178 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.
Perneczky Robert R Ghosh Boyd C P BC Hughes Laura L Carpenter Roger H S RH Barker Roger A RA Rowe James B JB
Neurobiology of disease 20110217 1
Brain regions related to saccadic control are affected by Parkinson's disease (PD) pathology and a relationship between abnormal saccades and cognitive features of PD has been suggested. We measured the latency of visually-evoked saccades, and correlated best-fit parameters in a LATER neuronal decision model μ and σ (mean and SD of the distribution of reciprocal latency, i.e. speed of response), and σ(E) (SD of the early component) with motor function, cognition and grey matter volume in 18 pati ...[more]
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