Ontology highlight
ABSTRACT:
SUBMITTER: Jiao S
PROVIDER: S-EPMC3102234 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Neuron 20110501 4
It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that caspase-3 is activated by the BAD-BAX cascade for LTD induction. This cascade is required specifically for NMDA receptor-dependent LTD but not for mGluR-LTD, and its activation is suf ...[more]