Ontology highlight
ABSTRACT:
SUBMITTER: Akey DL
PROVIDER: S-EPMC3102235 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Akey David L DL Razelun Jamie R JR Tehranisa Jason J Sherman David H DH Gerwick William H WH Smith Janet L JL
Structure (London, England : 1993) 20100101 1
Modular polyketide synthases (PKS) make novel natural products through a series of preprogrammed chemical steps catalyzed by an assembly line of multidomain modules. Each assembly-line step involves unique extension and modification reactions, resulting in tremendous diversity of polyketide products. Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate. We present crystal structures of the four dehydratase domains from the curacin A PKS. The ...[more]