Ontology highlight
ABSTRACT:
SUBMITTER: Mohammadi T
PROVIDER: S-EPMC3102273 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Mohammadi Tamimount T van Dam Vincent V Sijbrandi Robert R Vernet Thierry T Zapun André A Bouhss Ahmed A Diepeveen-de Bruin Marlies M Nguyen-Distèche Martine M de Kruijff Ben B Breukink Eefjan E
The EMBO journal 20110308 8
Bacterial cell growth necessitates synthesis of peptidoglycan. Assembly of this major constituent of the bacterial cell wall is a multistep process starting in the cytoplasm and ending in the exterior cell surface. The intracellular part of the pathway results in the production of the membrane-anchored cell wall precursor, Lipid II. After synthesis this lipid intermediate is translocated across the cell membrane. The translocation (flipping) step of Lipid II was demonstrated to require a specifi ...[more]