Ontology highlight
ABSTRACT:
SUBMITTER: Konig A
PROVIDER: S-EPMC3102283 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
König Annekatrin A Yatsenko Andriy S AS Weiss Miriam M Shcherbata Halyna R HR
The EMBO journal 20110318 8
Previously, it has been shown that in Drosophila steroid hormones are required for progression of oogenesis during late stages of egg maturation. Here, we show that ecdysteroids regulate progression through the early steps of germ cell lineage. Upon ecdysone signalling deficit germline stem cell progeny delay to switch on a differentiation programme. This differentiation impediment is associated with reduced TGF-β signalling in the germline and increased levels of cell adhesion complexes and cyt ...[more]