Ontology highlight
ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC3102288 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Xie Liangqi L Pelz Carl C Wang Wensi W Bashar Amir A Varlamova Olga O Shadle Sean S Impey Soren S
The EMBO journal 20110329 8
Although regulation of histone methylation is believed to contribute to embryonic stem cell (ESC) self-renewal, the mechanisms remain obscure. We show here that the histone H3 trimethyl lysine 4 (H3K4me3) demethylase, KDM5B, is a downstream Nanog target and critical for ESC self-renewal. Although KDM5B is believed to function as a promoter-bound repressor, we find that it paradoxically functions as an activator of a gene network associated with self-renewal. ChIP-Seq reveals that KDM5B is predom ...[more]