Ontology highlight
ABSTRACT:
SUBMITTER: Portal MM
PROVIDER: S-EPMC3102395 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20110510 21
General transcription factor IIH (TFIIH) is a complex RNA polymerase II basal transcription factor comprising 10 different polypeptides that display activities involved in transcription and DNA repair processes. Although biochemical studies have uncovered TFIIH importance, little is known about how the mRNAs that code for TFIIH subunits are regulated. Here it is shown that mRNAs encoding seven of the TFIIH subunits (p34, p44, p52, p62, XPB, CDK7, and p8) are regulated at the posttranscriptional ...[more]