Ontology highlight
ABSTRACT:
SUBMITTER: Jones PL
PROVIDER: S-EPMC3102409 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Jones Patrick L PL Pask Gregory M GM Rinker David C DC Zwiebel Laurence J LJ
Proceedings of the National Academy of Sciences of the United States of America 20110509 21
In insects, odor cues are discriminated through a divergent family of odorant receptors (ORs). A functional OR complex consists of both a conventional odorant-binding OR and a nonconventional coreceptor (Orco) that is highly conserved across insect taxa. Recent reports have characterized insect ORs as ion channels, but the precise mechanism of signaling remains unclear. We report the identification and characterization of an Orco family agonist, VUAA1, using the Anopheles gambiae coreceptor (AgO ...[more]