Ontology highlight
ABSTRACT:
SUBMITTER: Jin H
PROVIDER: S-EPMC3103361 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Jin Huajun H Kanthasamy Arthi A Anantharam Vellareddy V Rana Ajay A Kanthasamy Anumantha G AG
The Journal of biological chemistry 20110405 22
We previously demonstrated that protein kinase Cδ (PKCδ; PKC delta) is an oxidative stress-sensitive kinase that plays a causal role in apoptotic cell death in neuronal cells. Although PKCδ activation has been extensively studied, relatively little is known about the molecular mechanisms controlling PKCδ expression. To characterize the regulation of PKCδ expression, we cloned an ∼2-kbp 5'-promoter segment of the mouse Prkcd gene. Deletion analysis indicated that the noncoding exon 1 region conta ...[more]