Ontology highlight
ABSTRACT:
SUBMITTER: Kanda S
PROVIDER: S-EPMC3103399 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kanda Shoichiro S Harita Yutaka Y Shibagaki Yoshio Y Sekine Takashi T Igarashi Takashi T Inoue Takafumi T Hattori Seisuke S
Molecular biology of the cell 20110406 11
Transient receptor potential canonicals (TRPCs) play important roles in the regulation of intracellular calcium concentration. Mutations in the TRPC6 gene are found in patients with focal segmental glomerulosclerosis (FSGS), a proteinuric disease characterized by dysregulated function of renal glomerular epithelial cells (podocytes). There is as yet no clear picture for the activation mechanism of TRPC6 at the molecular basis, however, and the association between its channel activity and pathoge ...[more]