Ontology highlight
ABSTRACT:
SUBMITTER: Yao S
PROVIDER: S-EPMC3103603 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Yao Sheng S Zhu Yuwen Y Zhu Gefeng G Augustine Mathew M Zheng Linghua L Goode Diana J DJ Broadwater Megan M Ruff William W Flies Sarah S Xu Haiying H Flies Dallas D Luo Liqun L Wang Shengdian S Chen Lieping L
Immunity 20110428 5
CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from antigen-presenting cells. By employing a receptor array assay, we have demonstrated that B7-H2, best known as the ligand of inducible costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction ...[more]