Ontology highlight
ABSTRACT:
SUBMITTER: Lee DC
PROVIDER: S-EPMC3103775 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lee Deug-Chan DC Romero Roberto R Kim Chong Jai CJ Chaiworapongsa Tinnakorn T Tarca Adi L AL Lee JoonHo J Suh Yeon-Lim YL Mazaki-Tovi Shali S Vaisbuch Edi E Mittal Pooja P Draghici Sorin S Erez Offer O Kusanovic Juan Pedro JP Hassan Sonia S SS Kim Jung-Sun JS
Journal of immunology (Baltimore, Md. : 1950) 20100503 11
The mechanism of mouse parturition is thought to involve myometrial infiltration by amniotic fluid (AF) macrophages, activated by surfactant protein-A (SP-A). In humans, the concentration of AF SP-A decreases during labor, and no fetal macrophages are found in the myometrium after labor. Therefore, it appears that the mechanisms of labor in mice and humans are different. We investigated a potential role for SP-A in human pregnancy and parturition by examining SP-A expression patterns in AF and a ...[more]