Ontology highlight
ABSTRACT:
SUBMITTER: Lei T
PROVIDER: S-EPMC3104086 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Lei Tingjun T Srinivasan Supriya S Tang Yuan Y Manchanda Romila R Nagesetti Abhignyan A Fernandez-Fernandez Alicia A McGoron Anthony J AJ
Nanomedicine : nanotechnology, biology, and medicine 20101119 3
The purpose of this study was to compare the cellular uptake and cytotoxicity of targeted and nontargeted doxorubicin (DOX)-loaded poly(d,l-lactide co-glycolide) (PLGA) nanoparticle (NP) drug delivery systems in drug-resistant ovarian (SKOV-3) and uterine (MES-SA/Dx5) cancer cell lines. The cellular uptakes of DOX from nonconjugated DOX-loaded NPs (DNPs) and from HER-2 antibody-conjugated DOX-loaded NPs (ADNPs) in MES-SA/Dx5 cancer cells were higher compared to free DOX. Results also showed high ...[more]