Subcellular localization of SUN2 is regulated by lamin A and Rab5.
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ABSTRACT:
SUBMITTER: Liang Y
PROVIDER: S-EPMC3105078 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Subcellular localization of SUN2 is regulated by lamin A and Rab5.
Liang Ying Y Chiu Peng Hang PH Yip Kit Yan KY Chan Siu Yuen SY
PloS one 20110531 5
SUN2 is an inner nuclear membrane protein with a conserved Sad1/UNC-84 homology SUN-domain at the C-terminus. Intriguingly, SUN2 has also been reported to interact with Rab5, which localizes in early endosomes. To clarify the dual subcellular localization of SUN2, we investigated its localization in lamin A/C deficient cells rescued with lamin A or lamin C isoform, and in HeLa cells transfected with Rab5 or its mutants. We found that expression of lamin A but not lamin C partly restored the nucl ...[more]
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