Ontology highlight
ABSTRACT:
SUBMITTER: Gabriel G
PROVIDER: S-EPMC3105303 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature communications 20110101
Influenza A viruses are a threat to humans due to their ability to cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of the viral polymerase to importin-α, a cellular protein that mediates transport into the nucleus where transcription and replication of the viral genome takes place. In this study, we analysed replication, host specificity and pathogenicity of avian and mammalian influenza viruses, in ...[more]