Ontology highlight
ABSTRACT:
SUBMITTER: Mahapatra S
PROVIDER: S-EPMC3105386 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Mahapatra Sahasransu S Dewari Pooran S PS Dewari Pooran S PS Bhardwaj Anubhav A Bhargava Purnima P
Nucleic acids research 20110125 10
FACT complex is involved in elongation and ensures fidelity in the initiation step of transcription by RNA polymerase (pol) II. Histone variant H2A.Z is found in nucleosomes at the 5'-end of many genes. We report here H2A.Z-chaperone activity of the yeast FACT complex on the short, nucleosome-free, non-coding, pol III-transcribed yeast tRNA genes. On a prototype gene, yeast SUP4, chromatin remodeler RSC and FACT regulate its transcription through novel mechanisms, wherein the two gene-flanking n ...[more]