Ontology highlight
ABSTRACT:
SUBMITTER: Minczuk M
PROVIDER: S-EPMC3105396 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Minczuk Michal M He Jiuya J Duch Anna M AM Ettema Thijs J TJ Chlebowski Aleksander A Dzionek Karol K Nijtmans Leo G J LG Huynen Martijn A MA Holt Ian J IJ
Nucleic acids research 20110128 10
Here we show that c17orf42, hereafter TEFM (transcription elongation factor of mitochondria), makes a critical contribution to mitochondrial transcription. Inactivation of TEFM in cells by RNA interference results in respiratory incompetence owing to decreased levels of H- and L-strand promoter-distal mitochondrial transcripts. Affinity purification of TEFM from human mitochondria yielded a complex comprising mitochondrial transcripts, mitochondrial RNA polymerase (POLRMT), pentatricopeptide rep ...[more]