Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC3105411 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Yang Chenghua C van der Woerd Mark J MJ Muthurajan Uma M UM Hansen Jeffrey C JC Luger Karolin K
Nucleic acids research 20110129 10
MeCP2 is a highly abundant chromatin architectural protein with key roles in post-natal brain development in humans. Mutations in MeCP2 are associated with Rett syndrome, the main cause of mental retardation in girls. Structural information on the intrinsically disordered MeCP2 protein is restricted to the methyl-CpG binding domain; however, at least four regions capable of DNA and chromatin binding are distributed over its entire length. Here we use small angle X-ray scattering (SAXS) and other ...[more]