Ontology highlight
ABSTRACT:
SUBMITTER: Chodavarapu S
PROVIDER: S-EPMC3105425 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Chodavarapu Sundari S Felczak Magdalena M MM Kaguni Jon M JM
Nucleic acids research 20110202 10
We purified an inhibitor of oriC plasmid replication and determined that it is a truncated form of ribosomal protein L2 evidently lacking 59 amino acid residues from the C-terminal region encoded by rplB. We show that this truncated form of L2 or mature L2 physically interacts with the N-terminal region of DnaA to inhibit initiation from oriC by apparently interfering with DnaA oligomer formation, and the subsequent assembly of the prepriming complex on an oriC plasmid. Both forms of L2 also inh ...[more]