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The Prevalence of Functional Quorum-Sensing Systems in Recently Emerged Vibrio cholerae Toxigenic Strains.

ABSTRACT: Vibrio cholerae live in aquatic environments and cause cholera disease. Like many other bacteria, V. cholerae use quorum-sensing (QS) systems to control various cellular functions, such as pathogenesis and biofilm formation. However, some V. cholerae strains are naturally QS-defective, including defective mutations in the quorum sensing master regulator HapR. Here we examined the QS functionality of 602 V. cholerae clinical and environmental strains isolated in China from 1960-2007, by measuring QS-regulated gene expression. We found that a greater percentage of the toxigenic strains (ctxAB(+)) had functional QS as compared to the non-toxigenic strains (ctxAB(-)), and that this trend increased significantly over time. We hypothesize that QS provides adaptive value in V. cholerae pathogenic settings.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3107014 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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The Prevalence of Functional Quorum-Sensing Systems in Recently Emerged Vibrio cholerae Toxigenic Strains.

Wang Yunduan Y Wang Hui H Cui Zhigang Z Chen Haili H Zhong Zengtao Z Kan Biao B Zhu Jun J

Environmental microbiology reports 20110401 2

Vibrio cholerae live in aquatic environments and cause cholera disease. Like many other bacteria, V. cholerae use quorum-sensing (QS) systems to control various cellular functions, such as pathogenesis and biofilm formation. However, some V. cholerae strains are naturally QS-defective, including defective mutations in the quorum sensing master regulator HapR. Here we examined the QS functionality of 602 V. cholerae clinical and environmental strains isolated in China from 1960-2007, by measuring ...[more]

PMID: 21643457

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